Ghrl^tm1Mko
Targeted Allele Detail

Summary

• Symbol: Ghrl^tm1Mko
• Name: ghrelin; targeted mutation 1, Masayasu Kojima
• MGI ID: MGI:3709886
• Gene: Ghrl Location: Chr6:113693080-113696841 bp, - strand Genetic Position: Chr6, 52.84 cM, cytoband E3
• Alliance: Ghrl^tm1Mko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121019
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• The entire sequence has been deleted. Northern blot confirmed absence of transcript. (J:121019)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghrl Mutation: 7 strains or lines available

References

• Original: J:121019 Dezaki K, et al., Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes. 2006 Dec;55(12):3486-93
• All: 9 reference(s)