About   Help   FAQ
Rnf212repro57
Chemically induced Allele Detail
Summary
Symbol: Rnf212repro57
Name: ring finger protein 212; reproductive mutant 10, JAX Reproductive Mutagenesis Program
MGI ID: MGI:3708256
Gene: Rnf212  Location: Chr5:108877156-108922848 bp, - strand  Genetic Position: Chr5, 53.24 cM
Alliance: Rnf212repro57 page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU) (Null/knockout)
Mutation:    Single point mutation
 
Mutation detailsENU induced a C-to-T transversion at nucleotide 265 (at 108757107 bp in Chr5, GRCm38.p2) creating a premature stop codon in the coiled-coil domain of the gene. Western blot analysis confirmed the absence of protein expression in testes from homozygous mice. (J:219664)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rnf212 Mutation:  6 strains or lines available
Notes
Males are infertile: very low testis weight, low seminal vesicle weight, no epididymal sperm are recovered. Histological analysis shows arrest of spermatogenesis during late pachytene stage of meiotic prophase, some germ cells appear apoptotic.
References
Original:  J:92463 JAX Reproductive Mutagenesis Program, Heritable mouse mutants from The Jackson Laboratory Reproductive Genomics Mutagenesis Program. MGI Direct Data Submission. 2004-7;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
02/20/2024
MGI 6.23
The Jackson Laboratory