Rab27b^tm1Seab
Targeted Allele Detail

Summary

• Symbol: Rab27b^tm1Seab
• Name: RAB27B, member RAS oncogene family; targeted mutation 1, Miguel C Seabra
• MGI ID: MGI:3706985
• Synonyms: Rab27b^3lox
• Gene: Rab27b Location: Chr18:70112202-70274676 bp, - strand Genetic Position: Chr18, 43.89 cM
• Alliance: Rab27b^tm1Seab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120307
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• A floxed pgk-neo was inserted into intron 3 and a third loxP site was inserted into intron 1. (J:120307)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab27b Mutation: 28 strains or lines available

References

• Original: J:120307 Tolmachova T, et al., Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5872-7
• All: 1 reference(s)