Nxph3^tm1Mami
Targeted Allele Detail

Summary

• Symbol: Nxph3^tm1Mami
• Name: neurexophilin 3; targeted mutation 1, Markus Missler
• MGI ID: MGI:3705089
• Gene: Nxph3 Location: Chr11:95400671-95405380 bp, - strand Genetic Position: Chr11, 59.01 cM, cytoband C
• Alliance: Nxph3^tm1Mami page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119861
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and frt flanked neo cassette were inserted into intron 1, a flag epitope was added to the end of exon 2, and an IRES site, lacZ cassette and second loxP site were inserted into intron 2. LacZ expression was confirmed by a beta-galactosidase assay of parasagittal brain sections. (J:119861)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nxph3 Mutation: 12 strains or lines available

References

• Original: J:119861 Beglopoulos V, et al., Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination. Mol Cell Biol. 2005 Aug;25(16):7278-88
• All: 1 reference(s)