Man1a2^tm1Ahe
Targeted Allele Detail

Summary

• Symbol: Man1a2^tm1Ahe
• Name: mannosidase, alpha, class 1A, member 2; targeted mutation 1, Annette Herscovics
• MGI ID: MGI:3703788
• Synonyms: Man1B^f
• Gene: Man1a2 Location: Chr3:100469519-100592789 bp, - strand Genetic Position: Chr3, 43.71 cM
• Alliance: Man1a2^tm1Ahe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119977
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 2, as well as tk and neo selection markers. The selection markers were removed by transient transfection with Cre recombinase, leaving a floxed exon 2. (J:119977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Man1a2 Mutation: 31 strains or lines available

References

• Original: J:119977 Tremblay LO, et al., Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation. J Biol Chem. 2007 Jan 26;282(4):2558-66
• All: 1 reference(s)