Spry4^tm1.1Mrt
Targeted Allele Detail

Summary

• Symbol: Spry4^tm1.1Mrt
• Name: sprouty RTK signaling antagonist 4; targeted mutation 1.1, Gail R Martin
• MGI ID: MGI:3702553
• Synonyms: Spry4^flox
• Gene: Spry4 Location: Chr18:38719300-38734400 bp, - strand Genetic Position: Chr18, 20.5 cM
• Alliance: Spry4^tm1.1Mrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119280
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The entire open reading frame is floxed and the neo cassette has been removed by in vivo Flp mediated recombination. (J:119280)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spry4 Mutation: 43 strains or lines available

References

• Original: J:119280 Klein OD, et al., Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell. 2006 Aug;11(2):181-90
• All: 4 reference(s)