Igh^tm1Hws
Targeted Allele Detail

Summary

• Symbol: Igh^tm1Hws
• Name: immunoglobulin heavy chain complex; targeted mutation 1, Harry W Schroeder
• MGI ID: MGI:3702185
• Synonyms: DFL
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119391
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: ES cells containing the replacement of DQ52 with a loxP site were targeted with a vector containing a loxP neo cassette downstream of the DFL16.1 segment, flanking 12 of the 13 DH gene segments. (J:119391)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 47 strains or lines available

References

• Original: J:119391 Schelonka RL, et al., A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function. J Immunol. 2005 Nov 15;175(10):6624-32
• All: 1 reference(s)