Tg(Emx1-cre)1Ito
Transgene Detail

Summary

• Symbol: Tg(Emx1-cre)1Ito
• Name: transgene insertion 1, Shigeyoshi Itohara
• MGI ID: MGI:3701617
• Synonyms: Tg1
• Transgene: Tg(Emx1-cre)1Ito Location: unknown
• Alliance: Tg(Emx1-cre)1Ito page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Emx1-cre)1Ito expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Emx1 (MGI:95387)

• Mutation details: An Emx1 positive PAC clone frome the RPCI-21 PAC mouse genomic library (PAC-Emx1#1) was modified by the insertion of an NLS-Cre-poly(A) cassette into the NotI site by homologous recombination in bacteria. Two independent recombination events were identified. This transgenic line was generated from the PAC-Cre-A fragment and has 2-3 copies of the transgene. (J:88421)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Emx1 (mouse) Summary of all recombinase alleles driven by Emx1. Comparative matrix view of recombinase activities Alliance mouse Emx1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Adult expression of this transgene is seen in the olfactory bulb, neocortex, piriform cortex, hippocampus and amygdala of the brain. At 7-8 days of age expression is also observed in the inferior colliculus. Activity is primarily in excitatory neurons and astrocytes. Little or no activity is seen in inhibitory neurons.

References

• Original: J:88421 Iwasato T, et al., Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis. 2004 Mar;38(3):130-8
• All: 7 reference(s)