Trpm4^tm1Mfre
Targeted Allele Detail

Summary

• Symbol: Trpm4^tm1Mfre
• Name: transient receptor potential cation channel, subfamily M, member 4; targeted mutation 1, Marc Freichel
• MGI ID: MGI:3700526
• Synonyms: Trpm4^L3F2
• Gene: Trpm4 Location: Chr7:44952579-44983495 bp, - strand Genetic Position: Chr7, 29.24 cM
• Alliance: Trpm4^tm1Mfre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118679
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting construct was designed to insert loxP sites to flank exons 15 and 16 and to put a neo and a third loxP site into intron 16. These exons encode the first transmembrane domain. (J:118679)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm4 Mutation: 57 strains or lines available

References

• Original: J:118679 Vennekens R, et al., Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol. 2007 Mar;8(3):312-320
• All: 4 reference(s)