Tg(Tcra172,Tcrb172)1Wcl
Transgene Detail

Summary

• Symbol: Tg(Tcra172,Tcrb172)1Wcl
• Name: transgene insertion 1, Warren C Ladiges
• MGI ID: MGI:3699517
• Transgene: Tg(Tcra172,Tcrb172)1Wcl Location: unknown
• Alliance: Tg(Tcra172,Tcrb172)1Wcl page

Transgene origin

• Strain of Origin: (SWR x DBA/1LacJ)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra172,Tcrb172)1Wcl expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Rearranged Valpha11.1 and Vbeta8.2 TCR chain genes including the endogenous promoter regions were isolated from Type II collagen-specific T-cell hybridoma 172 and then were ligated together. The resulting single construct was used to generate transgenic mice. (J:118789)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:118789 Osman GE, et al., Expression of a type II collagen-specific TCR transgene accelerates the onset of arthritis in mice. Int Immunol. 1998 Nov;10(11):1613-22
• All: 4 reference(s)