Surf1tm2.1Zev
Targeted Allele Detail
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Symbol: |
Surf1tm2.1Zev |
Name: |
surfeit gene 1; targeted mutation 2.1, Massimo Zeviani |
MGI ID: |
MGI:3698400 |
Synonyms: |
Surf1loxP |
Gene: |
Surf1 Location: Chr2:26803393-26806542 bp, - strand Genetic Position: Chr2, 19.1 cM
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Alliance: |
Surf1tm2.1Zev page
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Germline Transmission: |
Earliest citation of germline transmission:
J:117871
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Parent Cell Line: |
AB1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: This allele results after the cre mediated excision of the neomycin resistance cassette in Surf1tm2Zev. The loxP remaining in exon 7 disrupts the reading frame from nucleotide 674 downstream of the cDNA and the replacement of the codon encoding N225 with a TAA stop codon. This frame shift would putatively result in the elimination of 81 amino acids from the carboxy terminus, however, no protein was detected by Western blot.
(J:117871)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Surf1 Mutation: |
14 strains or lines available
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Original: |
J:117871 Dell'agnello C, et al., Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice. Hum Mol Genet. 2007 Feb 15;16(4):431-44 |
All: |
6 reference(s) |
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