Ybx1^tm1Tuch
Targeted Allele Detail

Summary

• Symbol: Ybx1^tm1Tuch
• Name: Y box protein 1; targeted mutation 1, Takeshi Uchiumi
• MGI ID: MGI:3698273
• Synonyms: YB-1^-
• Gene: Ybx1 Location: Chr4:119135178-119151801 bp, - strand Genetic Position: Chr4, 55.34 cM, cytoband D1
• Alliance: Ybx1^tm1Tuch page

Exencephaly in Ybx1^tm1Tuch/Ybx1^tm1Tuch embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117977
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 5 and 6 were replaced with a neomycin resistance gene. (J:117977)

Expression

In Mice Carrying this Mutation:	44 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ybx1 Mutation: 18 strains or lines available

References

• Original: J:117977 Shibahara K, et al., Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C. Cancer Sci. 2004 Apr;95(4):348-53
• All: 3 reference(s)