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Gba1tm1Clk
Targeted Allele Detail
Summary
Symbol: Gba1tm1Clk
Name: glucosylceramidase beta 1; targeted mutation 1, Lorne A Clarke
MGI ID: MGI:3698018
Synonyms: FloxGBA
Gene: Gba1  Location: Chr3:89110235-89116273 bp, + strand  Genetic Position: Chr3, 39.01 cM
Alliance: Gba1tm1Clk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117763
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to flank exons 9-11 with loxP sites. An frt-flanked neo was inserted as well as exons 8-4 of metaxin 1 in reverse orientation. The neo was removed by transient expression of FLP recombinase. (J:117763)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gba1 Mutation:  43 strains or lines available
References
Original:  J:117763 Sinclair GB, et al., Generation of a conditional knockout of murine glucocerebrosidase: Utility for the study of Gaucher disease. Mol Genet Metab. 2007 Feb;90(2):148-56
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory