Hprt1^tm1Isrd
Targeted Allele Detail

Summary

• Symbol: Hprt1^tm1Isrd
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Isabelle Richard
• MGI ID: MGI:3697440
• Synonyms: CAFI
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^tm1Isrd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117658
• Parent Cell Line: BPES (ES Cell)
• Strain of Origin: (129-Hprt1^b-m3 x C57BL/6)F1

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The FRET calpain reporter was used in this allele, and consists of eYFP, a cleavage site of spectrin alpha 1, and eCFP. The reporter was placed under control of the CAG promoter and inserted into the locus. (J:117658)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1274 strains or lines available

References

• Original: J:117658 Bartoli M, et al., A mouse model for monitoring calpain activity under physiological and pathological conditions. J Biol Chem. 2006 Dec 22;281(51):39672-80
• All: 1 reference(s)