Agrp^tm1Mws
Targeted Allele Detail

Summary

• Symbol: Agrp^tm1Mws
• Name: agouti related neuropeptide; targeted mutation 1, Mark W Sleeman
• MGI ID: MGI:3696694
• Synonyms: Agrp^-
• Gene: Agrp Location: Chr8:106293327-106306477 bp, - strand Genetic Position: Chr8, 53.04 cM, cytoband D1-D2
• Alliance: Agrp^tm1Mws page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117539
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• The coding region was replaced with an in frame lacZ and a neomycin selectable marker. (J:117539)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agrp Mutation: 18 strains or lines available

References

• Original: J:117539 Wortley KE, et al., Agouti-related protein-deficient mice display an age-related lean phenotype. Cell Metab. 2005 Dec;2(6):421-7
• All: 2 reference(s)