Crim1^{Gt(KST264)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Crim1^{Gt(KST264)Byg}
• Name: cysteine rich transmembrane BMP regulator 1; gene trap KST264, BayGenomics
• MGI ID: MGI:3696690
• Synonyms: Crim1^KST264
• Gene: Crim1 Location: Chr17:78507677-78684021 bp, + strand Genetic Position: Chr17, 48.09 cM
• Alliance: Crim1^{Gt(KST264)Byg} page

Mutation origin

• Mutant Cell Line: KST264
• Germline Transmission: Earliest citation of germline transmission: J:117237
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1TMpfs Vector Type: secretory trap
• Mutation details: A gene trap vector containing sequence encoding a splice acceptor, transmembrane domain, beta-geo, IRES-PLAP and polyA signal, was inserted into intron 1. A shortened protein isoform lacking exon 2 is produced thus this is not a null mutation. (J:117237)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  KST264	CC144718 ; (MGI Seq Detail)	5' RACE	Chr17:78508282-78508527 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  2 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	90 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crim1 Mutation: 51 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:117237 Pennisi DJ, et al., Crim1(KST264/KST264) mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. Dev Dyn. 2007 Feb;236(2):502-11
• All: 9 reference(s)