Imab^CBA/H
QTL Variant Detail

Summary

• QTL variant: Imab^CBA/H
• Name: intermale aggressive behavior; CBA/H
• MGI ID: MGI:3696450
• QTL: Imab Location: unknown Genetic Position: ChrY, Syntenic

Variant origin

• Strain of Specimen: CBA/H

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:16307

Congenic line analysis mapped a locus involved in intermale aggression to the pseudoautosomal region of the Y Chromosome. This locus is called Imab (intermale aggressive behavior). Male animals from inbred strain NZB/BlNJ display more intense and frequent aggression towards other male mice compared to inbred strain CBA/H.

Male offspring from (CBA/H x NZB/BlNJ)F1 and (NZB/BlNJ x CBA/H)F1 mothers backcrossed to NZB/BlNJ fathers displayed significantly increased initiation of intermale aggressive behavior(69% -80%) compared to male offspring from F1 mothers backcrossed to CBA/H fathers (29%-38%) (P^{0.0002). No maternal effect was observed. These results indicate that Imab is linked to the Y chromosome and is independent of mtDNA.}

Congenic animals carrying Y chromosome non-pseudoautosomal (NPAR) DNA derived from CBA/H on an NZB/BlNJ genetic background were constructed (N.H-Y). The reciprocal congenic line H.N-Y^NPAR, which carries NZB/BlNJ-derived Y chromosome pseudoautosomal DNA on a CBA/H genetic background, was also constructed. Male congenic animals (at generations 29-30) did not differ in their attack intensity or frequency towards other male animals. Therefore Imab is excluded from the Y chromosome pseudoautosomal region.

References

• Original: J:16307 Roubertoux PL, et al., Co-segregation of intermale aggression with the pseudoautosomal region of the Y chromosome in mice. Genetics. 1994 Jan;136(1):225-30
• All: 1 reference(s)