Tg(ACTB-At5g20990)17Betz
Transgene Detail

Summary

• Symbol: Tg(ACTB-At5g20990)17Betz
• Name: transgene insertion 17, Heinrich Betz
• MGI ID: MGI:3696419
• Synonyms: Cnx1^tg17
• Transgene: Tg(ACTB-At5g20990)17Betz Location: unknown
• Alliance: Tg(ACTB-At5g20990)17Betz page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-At5g20990)17Betz expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  arabidopsis	B73 (832224)

• Mutation details: The transgene expresses the Arabidopsis thaliana ortholog of mammalian gephyrin variously known as CNX, CNX1, CHL6 or SIR4. Both the plant and mammalian proteins participate in the biosynthesis of molybdenum cofactor (MoCo), a metalloprotein coenzyme essential to the activity of several oxidoreductases. The A. thaliana cDNA resides downstream of a human beta-actin promoter and is followed by an SV40 polyadenylation signal. (J:82133)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Of 13 transgene-positive lines, the two exhibiting the highest transgene expression in brain and liver, designated by the authors Cnx1^tg12 and Cnx1^tg17, were employed in crosses to produce transgenic mice lacking gephyrin.

References

• Original: J:82133 Grosskreutz Y, et al., Rescue of molybdenum cofactor biosynthesis in gephyrin-deficient mice by a Cnx1 transgene. Biochem Biophys Res Commun. 2003 Feb 7;301(2):450-5
• All: 1 reference(s)