Syt2^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Syt2^tm1Sud
• Name: synaptotagmin II; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:3696107
• Gene: Syt2 Location: Chr1:134574272-134680887 bp, + strand Genetic Position: Chr1, 58.24 cM
• Alliance: Syt2^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117050
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-7 were replaced with an IRES-betageo cassette. Absence of protein was confirmed by Western blot analysis. X-gal staining detected lacZ expression in the spinal cord. (J:117050)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syt2 Mutation: 38 strains or lines available

References

• Original: J:117050 Pang ZP, et al., Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci. 2006 Dec 27;26(52):13493-504
• All: 12 reference(s)