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Targeted Allele Detail
Symbol: Eps8tm1Ppdf
Name: epidermal growth factor receptor pathway substrate 8; targeted mutation 1, Pier Paolo Di Fiore
MGI ID: MGI:3693626
Synonyms: Eps8-
Gene: Eps8  Location: Chr6:137454243-137626395 bp, - strand  Genetic Position: Chr6, 66.78 cM
Alliance: Eps8tm1Ppdf page
Disorganized stereocilia in Eps8l2tm1Wma/Eps8l2tm1Wma Eps8tm1Ppdf/Eps8tm1Ppdf mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:116237
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced one exon and part of a second exon. (J:116237)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eps8 Mutation:  108 strains or lines available
Original:  J:116237 Scita G, et al., EPS8 and E3B1 transduce signals from Ras to Rac. Nature. 1999 Sep 16;401(6750):290-3
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory