Rims1^tm2Sud
Targeted Allele Detail

Summary

• Symbol: Rims1^tm2Sud
• Name: regulating synaptic membrane exocytosis 1; targeted mutation 2, Thomas C Sudhof
• MGI ID: MGI:3693318
• Synonyms: RIM1 S413A-KI
• Gene: Rims1 Location: Chr1:22356475-22845203 bp, - strand Genetic Position: Chr1, 8.54 cM, cytoband A5
• Alliance: Rims1^tm2Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118932
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: Exon 6 was replaced with one in which nucleotide substitutions result in an amino acid substitution of alanine for serine at position 413 (S413A). A loxP site was inserted upstream of the modified exon 6 and an frt-flanked, double neo cassette with a 5' loxP site was inserted downstream of exon 6 and removed by germ line, flp mediated recombination. (J:142749)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rims1 Mutation: 87 strains or lines available

References

• Original: J:118932 Sudhof TC, Disruption of Rims1 in mice results in aberrant synaptic transmission in the CNS and poor maternal care. MGI Direct Data Submission. 2007
• All: 3 reference(s)