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Targeted Allele Detail
Symbol: Scn10atm3(cre/ERT2)Jwo
Name: sodium channel, voltage-gated, type X, alpha; targeted mutation 3, John N Wood
MGI ID: MGI:3689893
Synonyms: Nav1.8-CreERT2, Scn10atm3(cre/ERT2)Jnw
Gene: Scn10a  Location: Chr9:119437522-119548388 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband distal
Alliance: Scn10atm3(cre/ERT2)Jwo page
Germline Transmission:  Earliest citation of germline transmission: J:114488
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Scn10atm3(cre/ERT2)Jwo expression driven by 1 gene
Mutation detailsCre recombinaseERT2 cDNA, 3' UTR of Scn10a, and an FRT flanked neo were knocked into the initiator methionine so that Cre replaced the ATG. Crossing with mice expressing Flp recombinase in the germ line excised the floxed neo. (J:114488)
 Tissue activity of this recombinase allele
Driver: Scn10a (mouse)
Summary of all recombinase alleles driven by Scn10a.

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Scn10a Mutation:  102 strains or lines available
Original:  J:114488 Zhao J, et al., Tamoxifen-inducible NaV1.8-CreERT2 recombinase activity in nociceptive neurons of dorsal root ganglia. Genesis. 2006 Aug;44(8):364-71
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory