Ptprj^tm1Fus
Targeted Allele Detail

Summary

• Symbol: Ptprj^tm1Fus
• Name: protein tyrosine phosphatase receptor type J; targeted mutation 1, Alfredo Fusco
• MGI ID: MGI:3664243
• Synonyms: Ptprj^-
• Gene: Ptprj Location: Chr2:90260098-90410939 bp, - strand Genetic Position: Chr2, 50.19 cM, cytoband E1-2
• Alliance: Ptprj^tm1Fus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112807
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A targeting vector was designed to replace exons 3-5 with a cassette containing the EN2 intronic sequences, a splice acceptor site, an IRES-lacZ and a neo cassette with a polyA signal. Western blot failed to detect protein in mutant liver samples. (J:112807)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprj Mutation: 70 strains or lines available

References

• Original: J:112807 Trapasso F, et al., Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis. DNA Cell Biol. 2006 Jun;25(6):376-82
• All: 5 reference(s)