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Tg(Myh6-Ngfb)4Fed
Transgene Detail
Summary
Symbol: Tg(Myh6-Ngfb)4Fed
Name: transgene insertion 4, Howard J Federoff
MGI ID: MGI:3664113
Synonyms: MHC-NGF, Tg(Ngfb)1Fed
Transgene: Tg(Myh6-Ngfb)4Fed  Location: unknown  
Alliance: Tg(Myh6-Ngfb)4Fed page
Transgene
origin
Strain of Origin:  C3HeB/FeJ
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Ngfb)4Fed expresses 2 genes
 
Mutation detailsThis transgene consists of a 654-bp fragment of rat alpha-myosin heavy chain promoter inserted upstream of a chimeric Ngfb mini-gene containing noncoding exon 1 and a portion of intron 1 of the mouse Ngfb gene fused to sequences from intron 3 through exon 4 of the rat Ngfb gene. Northern blots analysis shows cardiac specific expression of Ngfb. Three lines were established (2-4), with line 4 containing 8-10 copies of the transgene and lines 2 and 3 containing between 15 and 20 copies. Line 4 is chosen as a representative line as it continues to exhibit the cardiac pathology due to hypomethylation while lines 2 and 3 are hypermethylated and show loss of the phenotype after propagation for about 10 generations. (J:25270)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:25270 Hassankhani A, et al., Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells. Dev Biol. 1995 May;169(1):309-21
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory