Igfbp5^tm1Jep
Targeted Allele Detail

Summary

• Symbol: Igfbp5^tm1Jep
• Name: insulin-like growth factor binding protein 5; targeted mutation 1, John E Pintar
• MGI ID: MGI:3663363
• Gene: Igfbp5 Location: Chr1:72897224-72914024 bp, - strand Genetic Position: Chr1, 36.94 cM
• Alliance: Igfbp5^tm1Jep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112029
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1, including the translation start site, was replaced by a neomycin resistance cassette. Northern blot failed to detect transcript from mutant kidney. RT-PCR failed to detect transcript in mutant brain, heart, and liver. (J:112029)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igfbp5 Mutation: 19 strains or lines available

References

• Original: J:112029 Ning Y, et al., Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5. Mol Endocrinol. 2006 Sep;20(9):2173-86
• All: 4 reference(s)