Pmm2^tm1Cthl
Targeted Allele Detail

Summary

• Symbol: Pmm2^tm1Cthl
• Name: phosphomannomutase 2; targeted mutation 1, Christian Thiel
• MGI ID: MGI:3663170
• Gene: Pmm2 Location: Chr16:8455467-8475472 bp, + strand Genetic Position: Chr16, 4.24 cM
• Alliance: Pmm2^tm1Cthl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111420
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 2. RT-PCR and Northern and Western blot failed confirmed successful ablation of the locus. (J:111420)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pmm2 Mutation: 24 strains or lines available

References

• Original: J:111420 Thiel C, et al., Targeted disruption of the mouse phosphomannomutase 2 gene causes early embryonic lethality. Mol Cell Biol. 2006 Aug;26(15):5615-20
• All: 1 reference(s)