Tg(tetO-Ipf1,lacZ)958.1Macd
Transgene Detail

Summary

• Symbol: Tg(tetO-Ipf1,lacZ)958.1Macd
• Name: transgene insertion 958-1, Raymond J MacDonald
• MGI ID: MGI:3655627
• Synonyms: Pdx1-nlacZ, tetO-Pdx1, tetO-Pdx1/lacZ, tetO-Pdx1-nlacZ, tetO-Pdx1/nlacZ, Tg^Pdx1, Tg^Pdx1-lacZ, Tg^Pdx1-nlacZ
• Transgene: Tg(tetO-Ipf1,lacZ)958.1Macd Location: unknown
• Alliance: Tg(tetO-Ipf1,lacZ)958.1Macd page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: A transgenic vector was generated containing an Ipf1 minigene (both exons linked with a shortened intron). The Ipf1 gene was preceded by a truncated 5' UTR and an IRES-linked beta-galactosidase (lacZ) gene under transcriptional control of 7 direct repeats of the tetracycline operator sequence (tetO) fused to the human cytomegalovirus immediate-early promoter. (J:103522)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:103522 Hale MA, et al., The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas. Dev Biol. 2005 Oct 1;286(1):225-37
• All: 1 reference(s)