Gabra1^tm3.1Geh
Targeted Allele Detail

Summary

• Symbol: Gabra1^tm3.1Geh
• Name: gamma-aminobutyric acid type A receptor subunit alpha 1; targeted mutation 3.1, Gregg E Homanics
• MGI ID: MGI:3654126
• Synonyms: HA
• Gene: Gabra1 Location: Chr11:42021766-42073757 bp, - strand Genetic Position: Chr11, 24.97 cM
• Alliance: Gabra1^tm3.1Geh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110982
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Cre mediated recombination removed the copy of fused exons 9 and 10, leaving the exon 9 with the knockin mutations to change serine 270 to histidine (S270H) and leucine 277 to alanine (L277A). (J:110982)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra1 Mutation: 47 strains or lines available

References

• Original: J:110982 Skvorak K, et al., Production of conditional point mutant knockin mice. Genesis. 2006 Jul;44(7):345-53
• All: 1 reference(s)