Cd80^tm1Lbgn
Targeted Allele Detail

Summary

• Symbol: Cd80^tm1Lbgn
• Name: CD80 antigen; targeted mutation 1, Laurence Bugeon
• MGI ID: MGI:3653492
• Gene: Cd80 Location: Chr16:38277793-38316682 bp, + strand Genetic Position: Chr16, 26.86 cM, cytoband B5
• Alliance: Cd80^tm1Lbgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110947
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 3 such that only expression of the full-length form of Cd80 is disrupted. Expression of IgV-Cd80 was not disrupted. (J:110947)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd80 Mutation: 42 strains or lines available

References

• Original: J:110947 Bugeon L, et al., Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses. Eur J Immunol. 2001 Jan;31(1):118-27
• All: 1 reference(s)