Mtor^tm2Yam
Targeted Allele Detail

Summary

• Symbol: Mtor^tm2Yam
• Name: mechanistic target of rapamycin kinase; targeted mutation 2, Shinya Yamanaka
• MGI ID: MGI:3641530
• Synonyms: Frap1^tm2, mTOR^Flox
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^tm2Yam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91655
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The endogenous gene has been modified so that a 515-base pair segment of the genomic sequence containing some of intron 57 and the 5' end of exon 58, including the sequence encoding the last six amino acids and the translation termination codon, is flanked by loxP sites and followed by a cassette containing an internal ribosome entry site (IRES) and a fusion of the bacterial beta-galactosidase and neomycin resistance genes (Beta-geo). The mutation is designed to conditionally delete the C-terminal 6 amino acids essential for kinase activity. (J:92252)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 115 strains or lines available

References

• Original: J:91655 Center for Animal Resources and Development, Information obtained from the Center for Animal Resources and Development (CARD), Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan. Unpublished. 2004-2103
• All: 2 reference(s)