Acaca^tm2Sjw
Targeted Allele Detail

Summary

• Symbol: Acaca^tm2Sjw
• Name: acetyl-Coenzyme A carboxylase alpha; targeted mutation 2, Salih J Wakil
• MGI ID: MGI:3641125
• Synonyms: ACC1^lox
• Gene: Acaca Location: Chr11:84020498-84292477 bp, + strand Genetic Position: Chr11, 51.29 cM
• Alliance: Acaca^tm2Sjw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110200
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP flanked neo cassette was inserted into intron 21 and a single loxP site was inserted into intron 22. The neo cassette was then removed Cre mediated recombination leaving a floxed exon 22. (J:110200)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acaca Mutation: 124 strains or lines available

References

• Original: J:110200 Mao J, et al., Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8552-7
• All: 6 reference(s)