Polm^tm1Abnd
Targeted Allele Detail

Summary

• Symbol: Polm^tm1Abnd
• Name: polymerase (DNA directed), mu; targeted mutation 1, Antonio Bernad
• MGI ID: MGI:3629201
• Synonyms: Polmu^-
• Gene: Polm Location: Chr11:5777860-5788016 bp, - strand Genetic Position: Chr11, 3.87 cM
• Alliance: Polm^tm1Abnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97782
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to eplace exons 3-5 with a neomycin resistance gene. Western blot failed to detect protein in mutant mice. (J:97782)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Polm Mutation: 28 strains or lines available

References

• Original: J:97782 Lucas D, et al., Polymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts. Eur J Immunol. 2005 May;35(5):1601-11
• All: 9 reference(s)