Cxcl1^tm1Wabo
Targeted Allele Detail

Summary

• Symbol: Cxcl1^tm1Wabo
• Name: C-X-C motif chemokine ligand 1; targeted mutation 1, William A Boisvert
• MGI ID: MGI:3629087
• Synonyms: KC^-, KC/GRO-alpha^-
• Gene: Cxcl1 Location: Chr5:91039100-91040974 bp, + strand Genetic Position: Chr5, 44.78 cM, cytoband E-F
• Alliance: Cxcl1^tm1Wabo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107325
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette was inserted into the locus. (J:107325)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcl1 Mutation: 11 strains or lines available

References

• Original: J:107325 Boisvert WA, et al., Up-regulated expression of the CXCR2 Ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression. Am J Pathol. 2006 Apr;168(4):1385-95
• All: 14 reference(s)