Del(9Apoa1-Apoa4)1Hmez
Targeted Allele Detail

Summary

• Symbol: Del(9Apoa1-Apoa4)1Hmez
• Name: deletion, Chr 9, Hafid Mezdour 1
• MGI ID: MGI:3628802
• Synonyms: Apoa1/Apoc3/Apoa4^tm1Hmez, Apoa1/c3/a4^-
• Gene: Del(9Apoa1-Apoa4)1Hmez Location: unknown Genetic Position: Chr9, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109005
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(9Apoa1-Apoa4)1Hmez involves 3 genes/genome features (Apoa1, Apoc3, Apoa4) View all
• Mutation details: A neomycin resistance gene replaced the coding sequences of apolipoprotein A-I, apolipoprotein C-III and the first two exons of apolipoprotein A-IV. Northern blot of mutant liver and intestine demonstrated successful ablation of expression of all three genes. Western blot confirmed absence of protein of each gene. (J:109005)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(9Apoa1-Apoa4)1Hmez Mutation: 0 strains or lines available

References

• Original: J:109005 Mezdour H, et al., Characterization of a new mouse model for human apolipoprotein A-I/C-III/A-IV deficiency. J Lipid Res. 2006 May;47(5):912-20
• All: 1 reference(s)