Pth1r^tm4Hmk
Targeted Allele Detail

Summary

• Symbol: Pth1r^tm4Hmk
• Name: parathyroid hormone 1 receptor; targeted mutation 4, Henry M Kronenberg
• MGI ID: MGI:3628795
• Synonyms: PTHR^D
• Gene: Pth1r Location: Chr9:110551153-110576213 bp, - strand Genetic Position: Chr9, 60.56 cM, cytoband F
• Alliance: Pth1r^tm4Hmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108984
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to mutate the EKKY in the second intracellular loop to DSEL. A neomycin gene inserted into the intron between exons E1 and E2 was subsequently removed via transient cre expression. (J:108984)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pth1r Mutation: 28 strains or lines available

References

• Original: J:108984 Guo J, et al., The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev Cell. 2002 Aug;3(2):183-94
• All: 3 reference(s)