Ptgs2^tm1Fun
Targeted Allele Detail

Summary

• Symbol: Ptgs2^tm1Fun
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1, Colin D Funk
• MGI ID: MGI:3628614
• Synonyms: PGHS-2^Y385F, Ptgs2^Y385F-Neo
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^tm1Fun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108957
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An A to T base change was introduced into exon 8 which caused the substitution of tyrosine, residue 385, with phenylalanine (Y385F). Numbering is based on numbering for the sheep protein. The actual mouse modification is Y371F. A floxed neomycin resistance cassette was introduced in intron 9. The cyclooxygenase function was inactivated but not the peroxidase function. (J:109548)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 72 strains or lines available

References

• Original: J:108957 Cheng Y, et al., Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest. 2006 May;116(5):1391-9
• All: 3 reference(s)