Krt12^tm3(cre)Wwk
Targeted Allele Detail

Summary

• Symbol: Krt12^tm3(cre)Wwk
• Name: keratin 12; targeted mutation 3, Winston W Y Kao
• MGI ID: MGI:3624816
• Synonyms: K12^Cre, Krt12^Cre, Krt12-Cre
• Gene: Krt12 Location: Chr11:99306492-99313085 bp, - strand Genetic Position: Chr11, 62.92 cM
• Alliance: Krt12^tm3(cre)Wwk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108338
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Krt12^tm3(cre)Wwk expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt12 (MGI:96687)

• Mutation details: An IRES-cre minigene was inserted into the site immediately behind the stop codon in exon 8. The mutant allele encodes a bicistronic mRNA with cre recombinase being under the control of the endogenous regulatory sequences. (J:108338, J:164088)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt12 (mouse) Summary of all recombinase alleles driven by Krt12. Comparative matrix view of recombinase activities Alliance mouse Krt12 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Krt12 Mutation: 24 strains or lines available

References

• Original: J:108338 Tanifuji-Terai N, et al., Expression of keratin 12 and maturation of corneal epithelium during development and postnatal growth. Invest Ophthalmol Vis Sci. 2006 Feb;47(2):545-51
• All: 6 reference(s)