Igkc^tm1Schz
Targeted Allele Detail

Summary

• Symbol: Igkc^tm1Schz
• Name: immunoglobulin kappa constant; targeted mutation 1, Pierre Sanchez
• MGI ID: MGI:3624131
• Synonyms: Ckappa^-
• Gene: Igkc Location: Chr6:70703419-70703738 bp, + strand Genetic Position: Chr6, 32.04 cM, cytoband C
• Alliance: Igkc^tm1Schz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108003
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the HpaI site of the constant kappa segment. Mutant mice did not express the kappa light chain in B cells. (J:108003)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igkc Mutation: 9 strains or lines available

References

• Original: J:108003 Sanchez P, et al., Compartmentalization of lambda subtype expression in the B cell repertoire of mice with a disrupted or normal C kappa gene segment. Int Immunol. 1994 May;6(5):711-9
• All: 5 reference(s)