Pomgnt1^{Gt(OST179231)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Pomgnt1^{Gt(OST179231)Lex}
• Name: protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase; gene trap OST179231, Lexicon Genetics
• MGI ID: MGI:3623521
• Synonyms: POMGnT1^-, Pomgnt1^{Gt(Betageo-btk)1Lex}
• Gene: Pomgnt1 Location: Chr4:116007700-116017041 bp, + strand Genetic Position: Chr4, 53.1 cM, cytoband C7
• Alliance: Pomgnt1^{Gt(OST179231)Lex} page

Mutation origin

• Mutant Cell Line: OST179231
• Germline Transmission: Earliest citation of germline transmission: J:107697
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing Betageo-btk was inserted into exon 2 of the locus in the 5' UTR, 35 nucleotides upstream of the start codon. Northern blot from mutant skeletal muscle confirmed absence of transcript. (J:107697)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST179231	CG559761 ; (MGI Seq Detail)	3' RACE	Chr4:116008364-116008439 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  5 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pomgnt1 Mutation: 63 strains or lines available

References

• Original: J:107697 Liu J, et al., A genetic model for muscle-eye-brain disease in mice lacking protein O-mannose 1,2-N-acetylglucosaminyltransferase (POMGnT1). Mech Dev. 2006 Mar;123(3):228-40
• All: 10 reference(s)