H19^tm6Tilg
Targeted Allele Detail

Summary

• Symbol: H19^tm6Tilg
• Name: H19, imprinted maternally expressed transcript; targeted mutation 6, Shirley M Tilghman
• MGI ID: MGI:3623136
• Synonyms: H19loxP
• Gene: H19 Location: Chr7:142129267-142131883 bp, - strand Genetic Position: Chr7, 87.97 cM
• Alliance: H19^tm6Tilg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57113
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The locus was flanked with loxP sites. A neo was included in the vector. Maternally inherited alleles expressed levels of RNA reduced to 60% of wild-type in liver and skeleton. Expression of the paternally inherited allele was not affected by the mutation. (J:57113)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H19 Mutation: 12 strains or lines available

References

• Original: J:57113 Schmidt JV, et al., Enhancer competition between H19 and Igf2 does not mediate their imprinting. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9733-8
• All: 1 reference(s)