Mapk11^tm2Jsca
Targeted Allele Detail

Summary

• Symbol: Mapk11^tm2Jsca
• Name: mitogen-activated protein kinase 11; targeted mutation 2, J Simon C Arthur
• MGI ID: MGI:3621932
• Synonyms: p38beta^ki
• Gene: Mapk11 Location: Chr15:89026685-89033809 bp, - strand Genetic Position: Chr15, 44.66 cM, cytoband E3
• Alliance: Mapk11^tm2Jsca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107771
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Single point mutation
• Mutation details: An Asp168Ala mutation was inserted into exon 7 via homologous recombination to create a kinase dead mutation. However expression of this allele was unexpectedly low and sequencing detected a single nucleotide polymorphism resulting in a Cys211Arg mutation in the ES cells. No RNA expression is detected in homozygous MEFs or in the cortex of homozygous mice. (J:107771)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk11 Mutation: 29 strains or lines available

References

• Original: J:107771 Beardmore VA, et al., Generation and characterization of p38beta (MAPK11) gene-targeted mice. Mol Cell Biol. 2005 Dec;25(23):10454-64
• All: 2 reference(s)