Ptpn11^tm2Bgn
Targeted Allele Detail

Summary

• Symbol: Ptpn11^tm2Bgn
• Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 2, Benjamin G Neel
• MGI ID: MGI:3621004
• Synonyms: Shp2 Ex2^-
• Gene: Ptpn11 Location: Chr5:121268596-121329460 bp, - strand Genetic Position: Chr5, 61.72 cM, cytoband F
• Alliance: Ptpn11^tm2Bgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106624
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing a splice acceptor, Beta-gal, and pgk-neo replaced exon 2 of the locus by homologous recombination. Western blot demonstrated that mutant mice expressed only a truncated protein. (J:106624)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn11 Mutation: 43 strains or lines available

References

• Original: J:106624 Yang W, et al., An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival. Dev Cell. 2006 Mar;10(3):317-27
• All: 1 reference(s)