Blm^tm2Khor
Targeted Allele Detail

Summary

• Symbol: Blm^tm2Khor
• Name: Bloom syndrome, RecQ like helicase; targeted mutation 2, Kyoji Horie
• MGI ID: MGI:3620978
• Gene: Blm Location: Chr7:80104839-80184896 bp, - strand Genetic Position: Chr7, 45.65 cM
• Alliance: Blm^tm2Khor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104881
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A cassette containing a single-chain reverse tetracycline-controlled trans-silencer (sc rtTS), a tetracycline-controlled transactivator (tTA), and a tetracycline responsive element (TRE) were introduced upstream of the translation start site in exon 2. The sc rtTS consists of two silencer moieties connected via a 36 amino acid linker. In the presence of doxycycline, the sc rtTS binds to tetO to suppress leaky expression of the locus. (J:104881, J:106458)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Blm Mutation: 87 strains or lines available

References

• Original: J:104881 The RIKEN BioResource Center, Information obtained from The RIKEN BioResource Center. Unpublished. 2006-2013
• All: 2 reference(s)