Mapk14^tm1Gab
Targeted Allele Detail

Summary

• Symbol: Mapk14^tm1Gab
• Name: mitogen-activated protein kinase 14; targeted mutation 1, Christopher A Gabel
• MGI ID: MGI:3620096
• Synonyms: p38alpha^-
• Gene: Mapk14 Location: Chr17:28910316-28967379 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^tm1Gab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60918
• Parent Cell Line: DBA-252 (ES Cell)
• Strain of Origin: DBA/1LacJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A construct was designed to replace ~8-10 kb of sequence from phenylalanine 129 to aspartic acid 283, including the TGY dual phosphorylation site, with a neomycin resistance cassette. (J:60918)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 43 strains or lines available

References

• Original: J:60918 Allen M, et al., Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med. 2000 Mar 6;191(5):859-70
• All: 2 reference(s)