Gata2^tm1Jeng
Targeted Allele Detail

Summary

• Symbol: Gata2^tm1Jeng
• Name: GATA binding protein 2; targeted mutation 1, James Douglas Engel
• MGI ID: MGI:3620070
• Synonyms: EIS-KI
• Gene: Gata2 Location: Chr6:88170873-88184014 bp, + strand Genetic Position: Chr6, 39.2 cM
• Alliance: Gata2^tm1Jeng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106045
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A GFP-neo cassette was inserted into exon IS, one of the two alternative untranslated first exons. The neo was removed via cre mediated excision. GFP expression was demonstrated only in the midbrain of mutant embryos. (J:106045)

Expression

In Mice Carrying this Mutation:

25 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata2 Mutation: 26 strains or lines available

References

• Original: J:106045 Suzuki N, et al., Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2202-7
• All: 2 reference(s)