Stat1^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Stat1^m1Btlr
• Name: signal transducer and activator of transcription 1; mutation 1, Bruce Beutler
• MGI ID: MGI:3619019
• Synonyms: Dom, Domino, Stat1^Dom
• Gene: Stat1 Location: Chr1:52158599-52201024 bp, + strand Genetic Position: Chr1, 26.81 cM
• Alliance: Stat1^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was identified in a screen of progeny of ENU-mutagenized mice for response to cytomegalovirus infection. It comprises a T-to-A transversion in exon 11 that results in replacement of valine by glutamic acid at amino acid position 319 (V319E), at the beginning of the DNA binding domain of the protein. Western blot analysis of macrophage protein detects low levels of STAT1. The protein fails to undergo normal phosphorylation of serine 727 or tyrosine 701 upon interferon treatment. (J:88776, J:105543)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stat1 Mutation: 72 strains or lines available

Notes

Mice carrying ENU mutations in this marker show higher susceptibility to mouse cytomegalovirus than that observed in susceptible BALB/c mice.

References

• Original: J:105543 Crozat K, et al., Analysis of the MCMV resistome by ENU mutagenesis. Mamm Genome. 2006 May;17(5):398-406
• All: 7 reference(s)