Kcnq4^tm1.1Tjj
Targeted Allele Detail

Summary

• Symbol: Kcnq4^tm1.1Tjj
• Name: potassium voltage-gated channel, subfamily Q, member 4; targeted mutation 1.1, Thomas J Jentsch
• MGI ID: MGI:3618993
• Synonyms: Kcnq4^-
• Gene: Kcnq4 Location: Chr4:120553335-120605809 bp, - strand Genetic Position: Chr4, 56.52 cM
• Alliance: Kcnq4^tm1.1Tjj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105924
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 6-8. The exon 6 within the vector contained a G286S substitution. After homologous recombination, Cre-recombinase treatment in the ES cells results in the elimination of exons 6-8 making a non-functional protein truncated at the beginning of the pore-forming P-segment. (J:105924)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnq4 Mutation: 36 strains or lines available

References

• Original: J:105924 Kharkovets T, et al., Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness. EMBO J. 2006 Feb 8;25(3):642-52
• All: 9 reference(s)