Srms^tm1Sia
Targeted Allele Detail

Summary

• Symbol: Srms^tm1Sia
• Name: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites; targeted mutation 1, Shinichi Aizawa
• MGI ID: MGI:3616183
• Gene: Srms Location: Chr2:180847356-180854964 bp, - strand Genetic Position: Chr2, 103.62 cM
• Alliance: Srms^tm1Sia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20410
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A lacZ gene and neomycin resistance cassette was inserted in to the exon encoding the fourth kinase domain. The lacZ gene was fused in-frame to the endogenous gene. Northern blot analysis demonstrated that no detectable transcript was expressed from this allele, and histochemical staining failed to detect beta-galactosidase in multiple tissues tested. (J:20410)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srms Mutation: 17 strains or lines available

References

• Original: J:20410 Kohmura N, et al., A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption. Mol Cell Biol. 1994 Oct;14(10):6915-25
• All: 2 reference(s)