Gphb5^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Gphb5^tm1Lex
• Name: glycoprotein hormone beta 5; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3615364
• Synonyms: GPB5^-, GPHB5-
• Gene: Gphb5 Location: Chr12:75458496-75463555 bp, - strand Genetic Position: Chr12, 32.71 cM
• Alliance: Gphb5^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105176
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 179-bp genomic region at exon 3 of the Gphb5 gene was deleted by a replacement-type vector with 10-kb homology arms. Thus, approximately half the open reading frame of Gphb5 was deleted and replace with an IRESLacZ/MC1-Neo selection cassette.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gphb5 Mutation: 8 strains or lines available

References

• Original: J:105176 Okada SL, et al., A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor. Mol Endocrinol. 2006 Feb;20(2):414-25
• All: 4 reference(s)