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QTL Variant Detail
QTL variant: Adip14SM/J
Name: adiposity 14; SM/J
MGI ID: MGI:3614988
QTL: Adip14  Location: unknown  Genetic Position: Chr9, Syntenic
Strain of Specimen:  SM/J
Allele Type:    QTL
Mutation:    Undefined
    Heterozygous animals exhibit increased retroperitoneal fat pad weight compared to homozygotes. (J:103841)
Inheritance:    Other (see notes)
View phenotypes and curated references for all genotypes (concatenated display).
Adip14 exhibits overdominance.

Mapping and Phenotype information for this QTL, its variants and associated markers


Linkage analysis was performed on 513 animals from a (SM/J x NZB/BlNJ)F2 intercross to identify QTL affecting obesity traits. Animals were placed on an atherogenic diet for 16 weeks before phenotyping. Parental strain SM/J exhibits smaller body size but higher adiposity compared to parental strain NZB/BlNJ.

Adip14 maps to 60 cM on mouse Chromosome 9 near D9Mit15 (LOD=3.9) with a 95% confidence interval spanning 48 cM - 60 cM. Adip14 exhibits overdominance as heterozygous animals exhibit increased retroperitoneal fat pad weights compared to SM/J or NZB/BlNJ homozygotes. Previously identified adiposity QTL Adip5 (42 cM) maps near the Adip14 interval.

Original:  J:103841 Stylianou IM, et al., Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm Genome. 2006 Jan;17(1):22-36
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory